In compliance with DECS Order No. 69, s. 1993, the Makati Science High School moved from Mayapis St., San Antonio Village to its new site, bounded by Osias, Palma and Gabaldon Streets in Poblacion in January, 1997. The whole school complex was finished sometime in December, 1997 in time for its inauguration.

It has four (4) 4-storey buildings with thirty-six classrooms.It majestically stands on a two thousand one hundred ninety-six square meter lot. Facilities have been made adequate to help maximize learning in Science and Technology, English and Mathematics, the subjects on focus. The Makati City-City School Board entered into an agreement with the EduQuest, Inc. for the implementation of the EduQuest curriculum – based technology integration program,inclusive of the use of courseware, academic support and technical services, and supply of computer hardware and accessories. Again, this is making available the use of audio visual softwares and hardwares.

Library resources include quality and updated books which are made available to the students from 7:00 in the morning to 6:00 in the evening.

The new Makati Science High School has its fully equipped audio-visual room, two (2) General Science laboratories, one (1) Biology laboratory, 2 Physics laboratories, 1 Chemistry laboratory, two (2) Computer laboratories, 1 Speech laboratory, Library facilities with available textbooks, resource books, newspapers and other reading materials, etc., and Knowledge Activity Center sponsored by EduQuest, one CAT-1 room, 1 Culinary Arts room, 2 Technology and Livelihood Educationm rooms, 1 Electronics laboratory, 1 Reading Center, 1 Environmental Education room, four (4) Music, Arts, Physical Education, and Health rooms, 1 Conference room, 1 Practice House, 1 Faculty room, 1 Supreme Student Government office, 1 Press room, 1 Service Bureau, 1 OIC room, and 16 classrooms.